Nickel-gallate metal–organic framework as an efficient antimicrobial and anticancer agent: in vitro study

Abstract Gallic acid is a natural antioxidant present in many plants such as tea, sumac, gallnut and other plants. This naturally occurring gallic known to exhibit auto-oxidation under certain conditions, generating several reactive oxygen species (ROS) including superoxides, hydroxyls hydrogen peroxide radicals that plays key roles its antimicrobial activity. Here, we demonstrate incorporating linker Ni-based metal organic frameworks (Ni-gallate MOFs) produces mesoporous nanostructures with anticancer The synthesized Ni-gallate MOFs have shown antibacterial activity against both Gram-positive Gram-negative bacteria, antifungal two different strains of fungi species. Furthermore, significant cytotoxic effect on rhabdomyosarcoma (RMS) cells, compared the standard drug, Doxorubicin. In this study, MOF were characterized using scanning electron microscope (SEM), energy dispersive X-ray (EDX), diffraction (XRD), Fourier transform infra-red (FTIR), Brunauer–Emmett–Teller (BET) method for surface area. acid-based framework nanostructure tested, suggesting has dual